Vitamin D₃ (cholecalciferol) 600 IU it is recommended as a dietary supplement - an additional source of vitamin D.

   The most important function of vitamin D₃ is to control calcium metabolism. Vitamin D₃ provides a balance of calcium and phosphorus in the blood. It is vital because a change in the concentration of calcium in the blood even by 1% causes severe disorders in the body:

• the excitability of nerve endings changes;
• muscle conduction is impaired;
• the penetration of minerals into cells worsens;
• the activity of many enzymes decreases;
• disturbed hormonal regulation of metabolism.

   Lack of vitamin D₃ in younger age causes in older children incorrect posture and curvature of the spine. It becomes the cause of joint mobility disorders in 30-year-olds and the development of arthritis in adults.

1 capsule contains: Vitamin D₃ - 15 mcg (600 IU).

* TR CU 022/2011 "Food products in terms of its labeling";
** Does not exceed the acceptable upper consumption level.

Dietary supplement "Vitamin D₃ (cholecalciferol) 600 IU" is registered by the Federal service for supervision of consumer protection and human welfare. Certificate of State Registration No. RU.77.99.88.003.R.003631.10.19 dated 03.10.2019, Technical Specifications (TS) 10.89.19-044-78056148-2019.

Composition: refined vegetable oil, vitamin D₃, capsule shell (gelatin, glycerin (water-retaining agent), water, sodium benzoate (preservative), ethyl vanillin (flavor)).

Release form: oval soft gelatin capsules weighing 410 mg, 60 capsules in consumer packaging.

Recommended use: Adults 1 capsule daily with a meal. The period of administration is 2-3 months. It is recommended consulting a doctor before administration. It is not a medicine.

Contraindications: Hypersensitivity of the components.

   Vitamin D₃ 1000 IU (cholecalciferol) is recommended as a dietary supplement – an additional source of vitamin D₃.

   Vitamin D contained in the drug contributes to rapid replenishment of vitamin D3 deficiency in the body, strengthening the immune system and reducing the risk of colds, better calcium absorption, strengthening bones and teeth, reducing the risk of osteoporosis, as well as maintaining the functional state of the cardiovascular, nervous system, reproductive function.

   Lack of vitamin D₃ in young children causes odd posture and curvature of the spine and causes mobility problems in the joints of 30-year-olds and the development of arthritis in older people.

   Taking vitamin D₃ in combination with other vitamins strengthens the immune system and is an excellent prophylactic against colds.

When the dietary supplement is consumed in the recommended dosage, the body will receive:

* according to the TR CU 022/2011 "Food products in terms of its labeling", Annex 2;
** the permissible upper level of consumption is not set, according to MR 2.3.1.0253-21 "Norms of physiological requirements for energy and nutrients for various groups of the population of the Russian Federation.

Certificate of state registration No. AM.01.01.01.003.R.000369.12.21 dated 28.12.2021 TU 10.89.19-060-78056148-2021

Ingredients: vegetable oil (sunflower), capsule shell (gelatin, glycerin (retaining agent), water, flavoring food "Ethylvanilin"), cholecalciferol (1000 IU of Vitamin D₃). The company produces products containing fish oil, lactose, and soy lecithin.

Release form: oval soft gelatin capsules weighing 570 mg, 30 or 90 capsules in consumer packaging.

Recommended use: Adults: 1 capsule daily with meals or as recommended by your doctor. The period of administration is one month. Repeated intake within a year is possible. It is not a medicine.

Contraindications: Hypersensitivity of the components pregnancy, and lactation. It is recommended to consult a doctor before administration.

Shelf life is two years.

Storage: keep in a dry place, out of the child's reach, at a temperature of no more than 25 °C.

      Vitamin D is the common name for a group of fat-soluble vitamins that have a multifaceted effect on the human body. One of the most important functions of vitamin D is to control the balance of calcium and phos-phorus in the blood. A 1% change in balance causes a serious disruption of the entire body. Two forms of vitamin D with similar characteristics are the most important: D₃ (cholecalciferol) and D₂ (ergocal-ciferol).

Vitamin D deficiency results in bone deformities (rickets) and increases the risk of fractures. Children with vitamin D deficiency tend to be more irritable, have poorer development (begin to walk later), and have a poor appetite. These manifestations are accompanied by delayed teething and dental enamel pathology [2].

According to many clinical studies, chronic vitamin D deficiency in young children is associated with a high risk of future development of various diseases: diabetes mellitus, obesity, autoimmune diseases, cancer, cardiovascular diseases, psoriasis, atopic diseases, inflammatory bowel diseases [3].

Sources of vitamin D

Vitamin D is formed in the skin by sunlight. Also, vitamin D is present in food: fatty fish (mackerel, salmon, sardine, tuna - 250 - 300 IU/100 g), egg yolk (20 IU in one chicken yolk), mushrooms (100 IU/100 g of fresh mushrooms) [4]. The formation of vitamin D in the skin under the influence of sunlight is influenced by geographic latitude, time of year, time of day, cloud cover, and degree of air pollution [5]. Given the geographical location of Russia, vitamin D is produced in sufficient quantities in the skin only on summer sunny days. A child should be exposed to direct sunlight for at least 30 minutes a week without clothes on, or 2 hours a week if only the face and limbs are covered [4]. People with dark skin have lower vitamin D production capacity, as melanin serves as a barrier to sunlight. Sunscreen with an SPF of 8 or higher reduces vitamin D production in the skin by 95% [6].

With food, a child receives on average 150 to 250 IU of vitamin D per day. The growing body's need for vitamin D is 5 to 10 times higher, and this is especially true for children of early childhood and adolescence [2].

Under the national program for the correction of vitamin D deficiency in children in the Russian Federation, adopted in 2018 the Union of Pediatricians of Russia recommends that children of all ages take preventive doses of vitamin D [7].

The recommended daily intake of dietary supplement (1 capsule) content.

* - according to methodical recommendations 2.3.1.2432-08 "Norms of physiological requirements for energy and nutrients for various groups of population of the Russian Federation";
** - according to the TR CU 022/2011 "Food products in terms of its labeling" (Annex 2);
*** - does not exceed the upper permissible level of consumption, according to "Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)" (Appendix 5).

Certificate of state registration No. RU.77.99.11.003.R.003713.11.20 dated 10.11.2020, Technical Specifications (TS) 10.89.19-051-78056148-2020.

Release form: round seamless soft gelatin capsules weighing 200 mg, 3 blisters of 10 capsules in a consumer packaging.

Ingredients: unrefined vegetable oil or a mixture of refined and unrefined oils (sunflower, or soybean, or olive), capsule shell (gelatin, glycerin (water-retaining agent), water, citric acid (acidity regulator)), vitamin D3 (cholecalciferol), dl-alpha-tocopherol (antioxidant). The company produces products containing fish oil, lactose, soy lecithin.

1 capsule contains: vitamin D₃ (cholecalciferol) - 10 micrograms (400 IU).

Scope: Recommended as a dietary food supplement - an additional source of vitamin D₃.

Recommended use: Adults and children over 3 years: 1 capsule 1 time a day with meals. The duration of intake is 1 month. Before using it is recommended to consult a doctor. Before using dietary supplements for children should consult a pediatrician.

Contraindications: Hypersensitivity to the components, pregnancy, and lactation.

Shelf life: 2 years.

Storage conditions: keep in a dry place, out of a child's reach at a temperature of no more than 25 °C.

______________________________________________________________________________________________________________

  Vitamin K₂ and D₃ are essential micronutrients that regulate calcium metabolism in the body. Calcium is a vital mineral that makes up bone tissue. Calcium ions also participate in blood clotting processes, regulate many biochemical functions - muscle contraction, cellular metabolism, including the secretion of hormones and neurotransmitters - substances that transmit impulses between cells. However, to get calcium in the bone tissue and organs: muscles, heart, brain, not enough to eat foods rich in calcium, you must create the conditions for proper digestion and metabolism of calcium in the body. Metabolic disorders lead to the deposition of calcium salts in various soft tissues and organs, causing diseases such as arthritis, gout, urolithiasis, etc. When calcium levels decrease, osteoporosis, osteochondrosis, hypertension, etc., develop.

The daily dosage (1 capsule) contains:

* - The recommended level of daily intake, according to the TR CU 022/2011 "Food products in terms of its labeling ," Appendix 2.
** - Adequate level of consumption per day, according to the Uniform Sanitary-Epidemiological and Hygienic Requirements for Goods Subject to Sanitary-Epidemiological Supervision (Control), Chapter II, Section 1, Appendix 5.
*** - Does not exceed the Upper Permissible level of consumption per day, according to the Uniform Sanitary-Epidemiological and Hygienic Requirements for Goods Subject to Sanitary-Epidemiological Supervision (Control), Chapter II, Section 1, Appendix 5.

Certificate of State Registration No. AM.01.06.01.003.R.000072.04.21 dated 30.04.2021, Technical Specifications (TS) 10.89.19-054-78056148-2021.

Ingredients: vegetable oil (sunflower), menaquinone-7 (120 micrograms of vitamin K₂), capsule shell (gelatin, glycerin (water-retaining agent), water, food flavoring "ethylvanillin"), cholecalciferol (200 IU vitamin D₃).

Dosage: soft gelatin capsules weighing 570 mg. The amount in a pack is 30 capsules.

Scope of use: as a food supplement is an additional source of vitamins K₂ and D₃.

Recommended use: Adults one capsule daily with a meal. The period of administration is one month. If necessary, the administration could be repeated. It is recommended to consult a doctor before administration. It is not medicine.

Ingredients: Hypersensitivity to the components. Pregnant and lactating women to take on the recommendation and under medical supervision.

Storage: Store in a dry place out of the reach of children at a temperature not exceeding 25 ^oC.

Shelf life: 2 years.

According to different sources, the average daily allowance of zinc ranges from 8 to 15 mg.

Food sources of zinc:

Oysters, beef, lamb, sesame and pumpkin seeds and pine nuts are the richest in zinc.

Health benefits

Zinc plays an essential role in supporting the health and normal functioning of the entire body. Among the main health benefits are:

• Participating in metabolism and cellular energy metabolism (it is part of enzymes that improve the absorption of nutrients and accelerate the removal of breakdown products from the body);
• stimulating the production of hormones (insulin, corticosteroids, testosterone), as well as nucleic acids, proteins, and other necessary substances for health;
• strengthening the immune system (has powerful antibacterial and antiviral properties, reduces the duration of colds);
• maintaining a healthy heart (regulates the flow of calcium ions into the heart cells and prevents oxidative stress by stimulating the production of antioxidant glutathione);
• improving digestion (normalizes intestinal permeability, improves absorption of nutrients, prevents diarrhea);
• stimulation of reproductive function (improves the quality of sex cells, supports the health of the prostate gland in men, affects the development of sexual organs in adolescent girls);
• normalization of blood sugar levels (regulates insulin secretion, increases the body's sensitivity to this hormone, reduces the risk of diabetes);
• regenerative functions (promotes healing of wounds and injuries, muscle growth and repair, necessary for children during development and women during pregnancy);
• improvement of brain functions (it is necessary for the proper perception of taste and smell, has a beneficial effect on memory, coordination, and thinking);
• providing vision support (maintains the health of the retina, prevents the development of cataracts, night blindness, age-related degenerative changes in the eye);
• improving skin (fights acne, eczema, and psoriasis) and hair (thickens the structure, prevents hair loss).

About Immunity

Zinc helps increase immune cell activity and enhances antibody production in response to infections. Zinc and its binders counteract the spread of viruses in the body. One hundred eighteen zinc-containing proteins support antiviral immunity.

Zinc deficiency is considered a risk factor for pneumonia. Separate studies show the effectiveness of zinc-containing medications in shortening symptoms and reducing the incidence of pneumonia.

Thus, zinc strengthens the immune system and helps reduce the risk of colds and viral diseases.

About vision

Zinc regulates the reactions of the visual cycle. With its protective antioxidant properties, zinc prevents oxidative damage to the pigment epithelium. The effect of zinc on the retina and the retinal pigment epithelium justifies its supplementary use in patients with age-related macular degeneration (AMD).

Zinc deficiency

According to modern studies, zinc deficiency affects about 2 billion people, i.e., every third inhabitant of our planet. The main causes of microelement deficiency are poor diet, excessive consumption of cereals, alcohol abuse, zinc malabsorption, liver and kidney disease. In addition, the concentration of zinc decreases in women during pregnancy and lactation and in the elderly.

Signs of zinc deficiency may include irritability, increased fatigue, visual impairment, memory problems, weight loss, deterioration of skin and hair, sleep disorders, and depression. Zinc deficiency can also result in an overabundance of iron, copper, lead, and cadmium.

Forms of zinc

When selecting a Zinc source, it is essential to pay attention to the substance since the bioavailability (absorption capacity) of different forms of zinc differs.

Percent assimilation is statistically average since in each case, the bioavailability of the mineral depends on the state of gastrointestinal mucous membranes, the body's individual need for zinc, hereditary metabolic diseases, the age of the person, taking other vitamins, minerals, and medicinal products, and other factors.

Any organic zinc compounds with amino acids (bisglycinate, gluconate, picolinate) can be called "chelate." Experts recommend choosing organic (chelated) forms of zinc because they are better absorbed and more effective against deficiencies of this trace element and related diseases.

The daily dosage (1 capsule) contains:

* Tolerance in accordance with specifications 10.89.19-058-78056148-2021;
** TR CU 022/2011 "Food products in terms of its labeling"; *** Does not exceed the upper permissible level of consumption according to "Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary and epidemiological supervision (control)" (Appendix 5).

Certificate of state registration No. AM.01.07.01.003.R.000055.02.21 dated 19.02.2021, Technical Specifications (TS) 10.89.19-058-78056148-2021.

Ingredients: microcrystalline cellulose (carrier), zinc bisglycinate (25 mg zinc), magnesium stearate (anti-caking agent), capsule shell (gelatin, titanium dioxide* (dye)). * For white capsules.

Release form: hard gelatin capsules weighing 326 mg, 30 or 100 capsules in a consumer packaging.

Directions for use: Adults: 1 capsule daily with meals. For conditions accompanied by the increased need for zinc - on the recommendation of the doctor. The duration of intake - at least a month. If necessary, the reception can be repeated. Before using it is recommended to consult with your doctor.

Contraindications: hypersensitivity to the components, pregnancy, and lactation.

Shelf life: 3 years.

Storage conditions: keep in a dry place, out of a child's reach at a temperature of no more than 25 °C

Zinc deficiency leads to immunodeficiency and cognitive disorders, increases sensitivity to infectious agents, increases the frequency of dermatitis, and slows wound healing. In particular, it is worth noting that in the elderly, zinc deficiency causes inhibition of protein biosynthesis, leading to a decrease in muscle tissue and an increase in fat tissue. Chronic zinc deficiency leads to the appearance or worsening of neurological and psychiatric disorders, such as depression and schizophrenia, as well as neurodegenerative diseases such as Alzheimer's, Parkinson's or amyotrophic lateral sclerosis. [1]

The antioxidant effect of zinc is crucial in reducing the severity of oxidative stress, which can cause DNA damage. Thus, zinc contributes to reducing the risk of cancer. Adequate intake of zinc contributes to an average acid-alkaline balance in the body. [2]

The crucial role of zinc in testosterone synthesis and spermatogenesis has been known for a long time. We can conclude that this trace element is essential for men during sexual activity to maintain normal sexual function and testosterone levels. In some cases, men with idiopathic infertility can restore reproductive function with increased zinc intake. [3]

An adequate supply of zinc to the visual structures ensures proper perception of light stimuli on the retina and reduces the risk of age-related macular degeneration. For older people, zinc consumption helps prevent the development of age-related macular degeneration and neurodegenerative diseases. [4]

Zinc is an effective immunostimulant that significantly reduces the duration of colds.

Selenium is part of more than two dozen selenium proteins (selenoproteins), which play a critical role in reproduction, thyroid hormone metabolism, DNA synthesis, and protection against oxidative damage and infections.

As part of the selenium protein glutathione peroxidase, selenium protects against free radicals and oxidative stress, supporting health at the cellular level. It is an active immunomodulator and a more powerful antioxidant than vitamins A, C, or E. [4]

Selenium proteins prevent oxidative modification of lipids, reducing inflammation and platelet adhesion. For these reasons, selenium supplements may reduce the risk of cardiovascular disease or cardiovascular-related deaths. [5]

Selenium is part of the enzyme that activates the primary thyroid hormone. Thus, selenium improves the absorption of iodine, and the thyroid gland deteriorates with a deficiency of selenium, resulting in a slower metabolism.

Selenium also supports prostate health and the immune system. Because of selenium's ability to repair chemical damage and breaks in DNA molecules, its active involvement in apoptosis (programmed death of diseased or old cells), and its effects on the human endocrine, immune, and antioxidant systems, selenium plays an essential role in cancer prevention. [6,7]

Thus, the components of the dietary supplement "Zinc + Selenium (Zn+Se)" contribute to:

• replenishment of zinc and selenium deficiency in the body;
• increasing antioxidant protection of body cells;
• protection of the body from the toxic effects of heavy metals;
• normalization of thyroid and adrenal function;
• normalization of acid-base balance;
• improving immunity (body's defenses) at high physical and mental stress, including in the "cold season;
• stabilization of metabolic processes in the body;
• support for the reproductive function of men and women;
• maintain healthy skin, hair, and nails;
• stabilization of the nervous and cardiovascular systems.

Ingredients: microcrystalline cellulose (carrier), zinc bisglycinate (25 mg zinc), capsule shell (gelatin, titanium dioxide* (dye)), magnesium stearate (anti-caking agent), 9-phenyl-simm-octahydroselenoxanthene (selenopyran) (0,07 mg of selenium).

The company produces products containing fish oil, lactose, and soy lecithin.

Release form: hard gelatin capsules weighing 315 mg, 30 or 100 capsules in a consumer packaging.

Directions for use: Adults: 1 capsule daily with meals or as recommended by a doctor. Duration of use: 1 month. Repeated intake within a year is possible. If necessary, the course of intake can be repeated for a year. Before using it is recommended to consult with a doctor. It is not a drug.

* Recommended Daily Intake Level (RDIL) in accordance with TR CU 022/2011 "Food products in terms of its labeling", Appendix 2

Certificate of state registration: No. AM.01.01.01.003.R.000182.05.22 dated 27.05.2022

Technical Specifications (TS) 10.89.19-062-78056148-2022

Contraindications: hypersensitivity to the components, pregnancy, and lactation.

Shelf life: 3 years.

Storage conditions: keep in a dry place, out of a child's reach at a temperature of no more than 25 °C.

    It is recommended as a dietary supplement - an additional source of vitamins A and E.

    Action of preparation is determined by the properties of its fat-soluble vitamins A and E.

    Retinyl palmitate (vitamin A) is a fat-soluble vitamin playing an essential role in oxidative-recovery processes, participates in the synthesis of complex carbohydrates, proteins, and fats. It is required for normal reproductive function, fetal development, restoration of skin and mucous membrane cells, and formation of bone tissue. It participates in vision mechanism. Retinyl increases the immunity, alleviates consequences of some infectious diseases, and may prevent the development of a malignant neoplasm.

    Alpha-tocopherol acetate (vitamin E) prevents the destruction of cell membranes, participates in protein synthesis, cell division processes, cellular respiration, favorably influences on disturbed lipid metabolism. Vitamin E maintains the stability of red corpuscles and prevents their decomposition, prevents increased permeability and capillary fragility, increases cellular resistance to an oxygen deficit. Vitamin E also promotes recovery of skeleton muscles at muscular dystrophy and other muscle injuries. At cardiovascular diseases in complex therapy, vitamin E promotes regulation of metabolism in heart muscle, increases the blood velocity and maintains potential in tiny vessels. Vitamin E also promotes regulation of the function of sex glands in men.

One capsule contains: alpha-tocopherol acetate - 100 mg (100 IU), retinyl palmitate - 4.7 mg (8,000 IU).

A daily serving contains:

** Does not exceed the acceptable upper level of consumption.

"Vitamins A+E" has the registration of the Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor). Certificate of State Registration No. RU.77.99.88.003.R.004303.11.21 dated 23.11.2021. Technical Specifications (TS) 10.89.19-033-78056148-2016.

Composition: vegetable unrefined or a mixture of a refined and unrefined oils (sunflower, or soya or, olive), alpha-tocopherol acetate, retinol palmitate, capsule shell (gelatin, glycerin (water-retaining agent), water, sodium benzoate (preservative), ethylvanillin (flavor)*).
*- for oval capsules

Recommended use: Adults 1 capsule one time daily with meals. The period of administration - 2-4 weeks. If required, the administration can be repeated in a month. It is recommended consulting a doctor before administration. It is not a medicine.

Contraindications: Hypersensitivity of the components, pregnancy, and lactation.